Logo
 

The ongoing/initiated research programs at Centre for Genomics include:

A. Molecular & Human Genetics
1. Tuberculosis: 
(a) HLA polymorphism in primitive tribes of central India, Sahariya and Bhil, in relation to genetic susceptibility and prevalence of Mycobacterial infections (Tuberculosis) in collaboration with the Department of Transplant Immunology, AIIMS, New Delhi (funded by ICMR).
(b) Chemokine and Chemokine receptor gene polymorphism and its association with Pulmonary Tuberculosis susceptibility in Tribal population of North Madhya Pradesh.
(c) Epidemiology of mycobacterial infection in tribes and other ethnic groups of Central India and detection of genetic polymorphism/strain of mycobacteria in relation to susceptibility to pulmonary tuberculosis.
2. Gall Bladder Cancer:
(a) Studies on the Molecular pathogenesis of gallbladder carcinoma to identify novel biomarkers by using high throughput proteomic and genomic strategies in collaboration with Institute of Bioinformatics, Bangalore and Cancer Hospital and Research Institute, Gwalior.
(b) Methylation profiling of gall bladder cancer and gall stone diseases to identify potential biomarkers for early disease diagnosis in collaboration with Cancer Hospital and Research Institute and GR Medical College and JA Hospital, Gwalior.
(c) Expression profiling of tumor associated genes in the molecular pathogenesis of gall bladder cancer in collaboration with Cancer Hospital and Research Institute and GR Medical College and JA Hospital, Gwalior.
(d) Epigenetic regulation of telomeres and expression of telomere length regulating factors in gall bladder cancer in collaboration with Cancer Hospital and Research Institute and GR Medical College and JA Hospital, Gwalior.
(e) Functional Validation of candidate genes in Gallbladder Cancer for identification of early biomarkers. 

B. Molecular Genetics Stress Genes & Proteins
(a) Molecular characterization and functional analysis of heat shock genes and proteins (HSPs) with special reference to development and stress tolerance in a fly model, blowfly Lucilia cuprina in collaboration with Centre for Cellular and Molecualr Biology, Hyderabad (funded by DST).

Centre for Genetic Diagnosis and Counseling:
Increased public awareness of the relationship between genetics and personal health has increased the demand for molecular genetic testing. The utility of molecular genetic testing is apparent in many settings, such as prenatal and pre-implantation diagnosis, risk assessment for familial cancer and the diagnosis of many neurological disorders. Such testing is also used to evaluate malignancies for diagnostic or staging purposes.
We at Centre for Genomics have initiated the process for developing a centre for genetic diagnosis and counseling which would provide expertise in DNA/molecular genetic testing for both congenital and inherited cancer syndromes. We have started our work in this aspect with diagnosis of Thalassemia and Spinocerebellar Ataxia patients. Our laboratory will persistently strive to develop new test methods that will improve patient care. In collaboration with professional doctors, laboratory technologists, supervisors and genetic counselors, we would continually work to improve assays by increasing mutation detection rates and decreasing turnaround time.

Research Projects (Completed)

Research Project 1

  • Project Title: Genetic Polymorphism in the tribal populations of North Madhya Pradesh in relation to genomic diversity and susceptibility to tuberculosis.
  • Duration: 3 years (2007-2009)
  • Name of the funding agency: DBT, Govt. of India, New Delhi.
Research Project 2
  • Project Title: Genetic diversity of HLA in the two tribal groups of North Madhya Pradesh: Association with pulmonary tuberculosis.
  • Duration: 3 years (2009-2012)
  • Name of the funding agency: ICMR, Govt. of India, New Delhi.
 Research Project 3
  • Project Title: Structural and functional characterization of hsp60 chaperonin related gene sequences in Sheep blowfly, Lucilla cuprina during development and heat stress.
  • Duration: 3 years (2009-2012)
  • Name of the funding agency: DST, Govt. of India, New Delhi
Research Project 4
  • Project Title: Study on genetic polymorphisms in Mycobacterium tuberculosis isolates from tuberculosis patients from Sahariya tribe of North Central India.
  • Duration: 3 years (2010-2013)
  • Name of the funding agency: ICMR, Govt. of India, New Delhi.

Research Projects (Ongoing)

Research Project 1
  • Project Title:  A study on the epigenetic regulation of telomeres and expression of telomere length regulating proteins in human gall bladder cancer.
  • Duration: 3 years (2011-2014)
  • Name of the funding agency: DAE-BRNS, Govt. of India, Mumbai.
Research Project 2
  • Project Title: Methylation profiling of gallbladder cancer and gall stone diseases to identify potential biomarkers for early disease diagnosis
  • Duration: 3 years (2012-2015)
  • Name of the funding agency: DST, Govt of India, New Delhi
Research Project 3
  • Project Title: Functional Validation of candidate genes in Gallbladder Cancer for identification of early biomarkers
  • Duration: 2 years (2013-2015)
  • Name of the funding agency: MPSCT, Govt. of Madhya Pradesh, Bhopal

Research Projects (Submitted)

Research Project 1
  • Investigation on Immunogenetic factors associated with pulmonary tuberculosis in Tribal and Non tribal Communities of Central India: Identification of potential diagnostic and therapeutic markers
Research Project 2
  • Association of Genetic Polymorphisms in PE_PGRS Genes of Mycobacterium tuberculosis Isolates  with  Innate Immune Response of PTB Patients from Sahariya Tribe of Madhya Pradesh